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butirosin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
BtrI_[glutamyl-carrier_protein] + L-glutamate + ATP <=> L-glutamyl-[BtrI_L-glutamyl-carrier_protein] + ADP + phosphate 6.2.1.39 [butirosin acyl-carrier protein]---L-glutamate ligase

butirosin_B <=> Butirosin_A 5.1.3

4-(gamma-L-glutamylamino)butanoyl-[BtrI_L-glutamyl-carrier_protein] + O2 + FMNH2 <=> 4-(gamma-L-glutamylamino)-(S)-2-hydroxy-butanoyl-[BtrI_L-glutamyl-carrier_protein] + H2O + FMN + H+ 1.14.14.13 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase

gamma-L-glutamyl-butirosin_B <=> butirosin_B + 5-oxoproline 4.3.2.6 gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

4-Aminobutyryl-[acp] + L-glutamate + ATP <=> 4-(gamma-L-glutamylamino)butanoyl-[BtrI_L-glutamyl-carrier_protein] + ADP + phosphate + H+ 6.2.1.39 [butirosin acyl-carrier protein]---L-glutamate ligase

4-(gamma-L-glutamylamino)-(S)-2-hydroxy-butanoyl-[BtrI_L-glutamyl-carrier_protein] + ribostamycin <=> gamma-L-glutamyl-butirosin_B + BtrI_[glutamyl-carrier_protein] + H+ 2.3.2.19 ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase

L-glutamyl-[BtrI_L-glutamyl-carrier_protein] + H+ <=> 4-Aminobutyryl-[acp] + CO2 4.1.1.95 L-glutamyl-[BtrI acyl-carrier protein] decarboxylase

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